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Fluvoxamine May Prevent Clinical Deterioration in Mild COVID-19

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Fluvoxamine, an antidepressant used to treat obsessive-compulsive disorder, may help prevent clinical deterioration of patients with mild coronavirus disease 2019 (COVID-19), results of an early clinical trial suggest.

The double-blind, placebo-controlled, randomized study, published in JAMA, included 152 outpatients with COVID-19 in the St. Louis area between April 10 and August 5. Over 15 days, clinical deterioration was reported in none of the participants who received fluvoxamine and in 6 (8.3%) of those who received a placebo.

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