eClinical Technology and Industy News

IncellDx: Two New Studies Offer a First Model for Diagnosing, Monitoring and Treating Long COVID

Excerpt from the Press Release:

SAN CARLOS, Calif.–(BUSINESS WIRE)–Two new studies propose the first model for diagnosing, indexing and monitoring Post-Acute Sequelae of COVID-19 (PASC), also known as long COVID or long haul COVID. The findings also provide a framework for understanding the cause of, and potential treatment for, long COVID. Long COVID is believed to affect as many as 30 percent of people who have recovered from initial infection with COVID-19.

In the study Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) Up to 15 Months Post-Infection conducted by IncellDx and available at bioRxiv, patients with previous COVID infection and lingering symptoms were found to have a distinct immunologic profile characterized by differentiated proportions of monocyte subsets. In the study, the presence of SARS-CoV-2 S1 protein was investigated in 46 people. T-cell, B-cell, and monocytic subsets were analyzed in both severe COVID-19 patients and in patients with post-acute sequelae of COVID-19 (PASC). The levels of both intermediate (CD14+, CD16+) and non-classical monocyte (CD14Lo, CD16+) were significantly increased compared with healthy controls. Neither monocyte subset was elevated in cases of severe COVID-19. Additionally, the SARS-CoV-2 protein subunit S1 was present in non-classical monocytes among patients thought to have PASC for up to 16 months following initial infection. Monocytes, a type of white blood cell, are involved in adaptive immunity and are instrumental in attacking viruses and other pathogens.

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