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GT Biopharma Presented Preclinical Data Demonstrating Novel Mesothelin-Targeted TriKE® Driving Cytotoxicity Across All Stages of Non-Small Cell Lung Cancer at ESMO TAT 2022

– Results suggest that mesothelin-targeted TriKE can work alongside current standard of care and provide benefit even in the hypoxic environment of a solid tumor

Excerpt from the Press Release:

BRISBANE, Calif., March 9, 2022 /PRNewswire/ — GT Biopharma, Inc. (NASDAQ: GTBP), a clinical stage immuno-oncology company focused on developing innovative therapeutics based on the Company’s proprietary tri-specific natural killer (NK) cell engager, TriKE® protein biologic technology platform, presented preclinical data demonstrating its novel TriKE driving NK cell immunotherapy against non-small cell lung cancer (NSCLC) in the hypoxic solid tumor microenvironment at ESMO’s Targeted Anticancer Therapies Congress (TAT).

Gregory Berk, M.D., the Company’s President of R&D and Chief Medical Officer noted, “This pre-clinical evidence suggests, despite the difference in circulating immune cells of Stage IVB NSCLC patients, a mesothelin-targeted TriKE can work alongside current standard of care and provide benefit even in the hypoxic environment of a solid tumor, meriting further investigation of this novel, targeted TriKE.”

Driving NK cell immunotherapy against NSCLC, in the context of hypoxia, using Tri-specific Killer Engager (TriKE®)

Background –Currently, Tri-specific killer engagers (TriKE®) are being tested in the clinic to treat leukemia and lymphoma. These TriKE’s cross-link CD16/FcγRIII and the tumor antigen on NK cells which drives cytotoxicity while IL15 provides survival and proliferation signals to NK cells. Mesothelin (MSLN), is currently a tumor antigen being targeted in various cancers including NSCLC. The current study conducted by Dr. Jeff Miller’s laboratory, University of Minnesota, evaluated whether a MSLN-targeted TriKE could drive cytotoxicity towards NSCLC cells at all stages of disease in the presence of hypoxia, a challenge in the NSCLC tumor microenvironment.

Study design and analysis –Using peripheral blood mononuclear cells (PBMC) collected from NSCLC patients, (1) before patients started standard treatment, (2) after initial treatment and (3) at disease progression where applicable.

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