Regulus Therapeutics Announces Initiation of Preclinical Studies in Amyotrophic Lateral Sclerosis under a Collaboration Agreement with Harvard’s Brigham and Women’s Hospital
– Preliminary data are expected in the second half of 2022
Excerpt from the Press Release:
SAN DIEGO, March 24, 2022 /PRNewswire/ — Regulus Therapeutics Inc. (Nasdaq: RGLS), a biopharmaceutical company focused on the discovery and development of innovative medicines targeting microRNAs (the “Company” or “Regulus”), today announced the initiation of studies evaluating a library of oligonucleotides designed to block miR-155 for the potential to treat Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig’s disease) under a collaboration agreement with the laboratories of Oleg Butovsky, Ph.D., and Howard L. Weiner, M.D., at Brigham and Women’s Hospital (BWH). The agreement, effective since September 2021, encompasses the investigation of the biologic effects of miR-155 inhibitors in both in vitro and in vivo models of ALS.
Dr. Butovsky is an Associate Professor of Neurology at Harvard Medical School and a Senior Scientist at BWH. Dr. Weiner is the Robert L. Kroc Professor of Neurology at the Harvard Medical School, Director and Founder of the Partners Multiple Sclerosis Center and Co-Director of the Center for Neurologic Diseases at BWH. The study plan focuses on the evaluation of the Regulus-designed compounds that inhibit miR-155 activity in microglia cell-based assays and in animal models of the disease, to identify potential candidates to advance into further studies. Results from these initial studies will be used to guide the design of future experiments in additional animal models of the disease and characterize their properties. Combined, these data will be used in an effort to identify anti-miR-155 lead compounds exhibiting robust pharmacologic profiles and enable their further preclinical therapeutic evaluation and initial testing in subjects with ALS.
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