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TransCode Therapeutics Acquires Option for Radiotheranostic Technology

Excerpt from the Press Release:

BOSTON, May 19, 2022 (GLOBE NEWSWIRE) — TransCode Therapeutics, Inc. (NASDAQ: RNAZ), the RNA oncology company committed to defeating cancer using RNA therapeutics, is pleased to announce its execution of an option agreement giving TransCode the right to negotiate an exclusive, worldwide, royalty-bearing license related to a radiotheranostic technology disclosed in patent application PCT/US2021/057912 entitled THERAPEUTIC, RADIOLABLED NANOPARTICLES AND METHODS OF USE THEREOF. Invented by TransCode Co-Founder and CTO, Dr. Zdravka Medarova, and her colleagues at Massachusetts General Hospital, the technology represents another potential advancement in the diagnosis and treatment of cancer.

“We are excited by the potential of radiolabeled therapeutics not just to augment the capabilities of our TTX delivery system, but also to enhance the activity of our existing and future RNA-based therapeutics in the treatment of multiple types and stages of cancer,” commented Michael Dudley, TransCode CEO.

The use of radioisotopes is a (re)emerging approach for many drug development companies in the treatment of cancer. There are a range of carriers from antibodies to small molecules that can be used to localize, penetrate and persist in tumors. TransCode is prosecuting the continued development of its iron-oxide based nanoparticle RNA delivery platform, dubbed TTX. Just as TTX has the potential to improve on the intracellular delivery of RNA therapeutics over existing lipid-based systems, TransCode believes TTX has the potential for efficient localized penetration of radioisotopes inside tumor cells.

Dr. Medarova added, “Our preclinical results demonstrated that PET–MRI following a microdose injection of the radiolabeled therapeutic accurately reflected the innate biodistribution of the therapeutic. The tools developed in the published study set the groundwork for the clinical testing of TTX-MC138Cu64 and other similar therapeutics in patients with cancer.”

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