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Vaxart Announces the Publication of Studies in the Peer-Reviewed Journal Science Translational Medicine That Suggest Mucosal Immunization Could Decrease SARS-CoV-2 Transmission

A preclinical study in hamsters showed both a decrease in infectious virus and in transmission

Phase 1 data measuring cross-reactivity also included in the publication

Excerpt from the Press Release:

SOUTH SAN FRANCISCO, Calif., May 19, 2022 (GLOBE NEWSWIRE) — Science Translational Medicine has published the results of a Duke University-led preclinical hamster transmission study that found that Vaxart’s (NASDAQ: VXRT) S-only oral COVID-19 vaccine candidate inhibited the transmission of SARS-CoV-2. The report also described updated results from Vaxart’s Phase I clinical trial that suggest Vaxart’s other vaccine candidate, the one targeting both the S and N proteins, could be effective against a range of diverse coronaviruses.

The study compared various measures of immunity and viral shedding in hamster cohorts immunized with Vaxart’s S-only vaccine candidate (administered orally and intranasally), an intramuscular protein vaccine control and placebo. The vaccinated hamsters were then infected with high doses of SARS-CoV-2 to create vaccine breakthrough and exposed to naïve animals during the breakthrough period. The study authors concluded that Vaxart’s S-only construct “reduced disease and decreased airborne transmission in a hamster model.”

The publication also reported results from the Phase I clinical study of Vaxart’s S+N vaccine candidate showing that it stimulated SARS-CoV-2-specific IgA antibodies in saliva and nasal samples from human subjects and was cross-reactive to many different coronaviruses that are more divergent than circulating variants of SARS-CoV-2.

“The publication of these results in a highly respected, peer-reviewed journal such as Science Translational Medicine underscores the potential value of Vaxart’s oral COVID-19 vaccine platform in solving multiple aspects of the COVID-19 pandemic,” said Dr. Sean Tucker, Vaxart’s Chief Scientific Officer and senior author on the publication.

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