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Pliant Therapeutics Announces Presentations at the International Liver Congress™ 2022 Highlighting Preclinical and Clinical Data in Support of the INTEGRIS-PSC Phase 2a Clinical Trial

Excerpt from the Press Release:

SOUTH SAN FRANCISCO, Calif., June 24, 2022 (GLOBE NEWSWIRE) — Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical stage biotechnology company focused on discovering and developing novel therapeutics for the treatment of fibrosis, today announced the presentation of two scientific posters at the International Liver Congress™ (ILC) 2022 of the European Association for the Study of the Liver (EASL), taking place June 22-26, 2022, in London, United Kingdom.

“Our presentations at this year’s International Liver Congress summarize the translational research findings supporting the hepatic antifibrotic activity of PLN-74809, an oral dual αvß/ αvß1 integrin inhibitor,” said Éric Lefebvre, M.D., Chief Medical Offer at Pliant Therapeutics. “Preliminary safety data from the INTEGRIS-PSC study continue to show a favorable tolerability profile for PLN-74809.”

The poster “Rationale for Evaluation of PLN-74809 Treatment in Participants with Primary Sclerosing Cholangitis in Phase a Study INTEGRIS-PSC” summarized preclinical data on the antifibrotic activity of PLN-74809 in two preclinical models of biliary fibrosis as well as in precision-cut liver slices from patients with primary sclerosing cholangitis (PSC) or primary biliary cirrhosis (PBC). Results showed dose-dependent reductions of key drivers of fibrosis in a mouse model of biliary fibrosis including hepatic collagen, collagen proportionate area, TGF-β signaling and cholestasis.

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