Q32 Bio Presents New Preclinical Data at the International Society of Nephrology Frontiers Meeting Demonstrating the Therapeutic Potential of ADX-097

Data show that C3d-mediated tissue targeting of factor H results in potent, durable and efficacious local complement blockade without systemic complement inhibition

Excerpt from the Press Release:

WALTHAM, Mass., June 23, 2022 /PRNewswire/ — Q32 Bio, a clinical stage biotechnology company developing biologic therapeutics to restore immune homeostasis, today announced that the Company presented new preclinical data demonstrating the therapeutic potential of ADX-097, Q32’s lead program for innate immunity. The data was presented by Stefan Wawersik, Ph.D., Q32’s Vice President of Research, in a poster presentation titled “C3d-Directed Factor H Targeting Delivers Potent and Durable Complement Inhibition and Disease-Modifying Efficacy in Kidney and Skin Without Inhibiting Systemic Complement,” at the International Society of Nephrology (ISN) “Complement-related kidney diseases: Classification, genetics and treatment” Frontiers Meeting held in Bergamo, Italy.

“Q32 is developing ADX-097 as a potent tissue targeted complement regulator that spares systemic complement blockade,” said Shelia Violette, Ph.D., Founder and Chief Scientific Officer of Q32 Bio. “The data presented at the ISN Frontiers Meeting provides important validation of our approach, describing how, in multiple preclinical models, including non-human primates, ADX-097 effectively inhibited complement activation in injured/diseased tissue while minimizing systemic blockade.”Study Results

ADX-097 is a bi-functional fusion protein comprising a humanized anti-C3d monoclonal antibody linked to two moieties of the first five consensus repeats of factor H and was designed to enable local inhibition of complement activation in diseased tissue while avoiding systemic complement blockade.

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