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New Data Suggest Veracyte’s Envisia Genomic Classifier Can Help Predict Disease Progression in Interstitial Lung Disease Patients Treated with Combination Immunosuppressive Therapy

Findings presented at the European Respiratory Society International Congress 2022

Excerpt from the Press Release:

SOUTH SAN FRANCISCO, Calif.–(BUSINESS WIRE)–Veracyte, Inc. (Nasdaq: VCYT) today announced new data suggesting that the Envisia Genomic Classifier (EGC) can help predict which patients with interstitial lung disease (ILD), including idiopathic pulmonary fibrosis (IPF), are likely to have progressive disease that declines with combination immunosuppressive therapy. These findings, shared at the European Respiratory Society (ERS) International Congress 2022 (Abstract #PA1948), are important because they show that the genomic test can help physicians make more-informed treatment decisions for their patients.

“Patients with IPF and other progressive ILDs are recommended for antifibrotic therapy,” said Athol Wells, M.D., Ph.D., consultant chest physician at Royal Brompton Hospital in London who presented the new findings in a poster presentation. “However, determining which patients have IPF or an ILD that will progress is often challenging. This can lead to treatment delays or, worse, empirical treatment with immunosuppressant therapy that may be harmful to some patients with progressive disease. Our findings suggest that the Envisia Genomic Classifier can identify patients whose ILD is likely to progress with combination immunosuppressive therapy and who thus could potentially benefit from antifibrotic therapy.”

The Envisia test identifies a genomic pattern of usual interstitial pneumonia (UIP), a critical factor in distinguishing IPF from non-IPF to help guide initial treatment, using tissue obtained through transbronchial biopsy. In the study, the researchers retrospectively analyzed data from 135 patients enrolled in the BRAVE trial who underwent evaluation for an undiagnosed ILD, had an EGC result and had multiple forced vital capacity (FVC) measurements to assess lung function over time.

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