eClinical Technology and Industy News

CinCor Pharma Announces Publication of Phase 1 Multiple Ascending Dose Study Data in Hypertension Research

Excerpt from the Press Release:

WALTHAM, Mass., Oct. 21, 2022 (GLOBE NEWSWIRE) — CinCor Pharma, Inc. (NASDAQ: CINC) today announced the publication of Phase 1 clinical data for baxdrostat, a highly selective, once daily, oral small molecule inhibitor of aldosterone synthase, in the journal Hypertension Research.

The publication includes clinical data from the company’s randomized, Phase 1, placebo controlled multiple ascending dose (MAD) study evaluating the safety, pharmacokinetics, and pharmacodynamics of baxdrostat in healthy volunteers. These data demonstrate baxdrostat is well tolerated with a half-life that supports once-daily oral dosing. The dose-dependent reduction in plasma aldosterone and lack of impact on cortisol reinforce the selective blockade of aldosterone synthase by baxdrostat.

“We believe these proof-of-concept data support further clinical advancement of this promising new treatment for hypertension,” said Mason Freeman, M.D., Chief Medical Officer at CinCor. “Importantly, these data provide the first clinical evidence that an aldosterone synthase inhibitor can block aldosterone production without impacting cortisol and support a well-tolerated and well-behaved pharmacokinetic profile across all doses of baxdrostat tested.”

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