Corcept Therapeutics Initiates DAZALS – A Phase 2 Trial in Amyotrophic Lateral Sclerosis (ALS)
Excerpt from the Press Release:
MENLO PARK, Calif., Oct. 11, 2022 (GLOBE NEWSWIRE) — Corcept Therapeutics Incorporated (NASDAQ: CORT), a commercial-stage company engaged in the discovery and development of medications to treat severe endocrine, oncologic, metabolic and neurological disorders by modulating the effects of the hormone cortisol, today announced that it has initiated DAZALS – a Phase 2 trial of its proprietary selective cortisol modulator dazucorilant in patients with amyotrophic lateral sclerosis (ALS).
“ALS, also known as Lou Gehrig’s disease, is a devastating neuromuscular illness with an urgent need for better treatment,” said Bill Guyer, PharmD, Corcept’s Chief Development Officer. “We are excited to initiate this important study in collaboration with TRICALS, the leading ALS academic consortium in Europe.”
“Dazucorilant showed great promise in animal models of ALS – improving motor performance and reducing neuroinflammation and muscular atrophy,” said principal investigator Dr. Leonard van den Berg, chairman of TRICALS and professor of neurology at the University Medical Center Utrecht in the Netherlands. “I am excited to partner with Corcept to study dazucorilant’s potential to significantly improve treatment outcomes for people living with ALS.”
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