Harbour BioMed Announces Dosing of First Patient in Phase I Trial of B7H4x4-1BB Bispecific Antibody in the United States
Excerpt from the Press Release:
CAMBRIDGE, Mass., ROTTERDAM and SUZHOU, China, Oct. 20, 2022 /PRNewswire/ — Harbour BioMed (“HBM”, HKEX: 02142) announced that, it has successfully completed the dosing of first patient in the global phase I trial of B7H4x4-1BB bispecific antibody HBM7008 in the United States. This study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of HBM7008 in patients with solid tumors.
HBM7008 is generated from Harbour BioMed’s unique and innovative HBICE® platform, leveraging the advantages of the HCAb and H2L2 platforms. It targets Tumor-Associated Antigen (B7H4), mediated crosslinking T cell activation through 4-1BB. B7H4 is overexpressed on a variety of solid malignancies, including breast, ovarian, endometrial, and non-small cell lung cancers. With its crosslinking dependent specificity on tumors and potent immune modulation activity, HBM7008 has shown excellent safety profile with strong anti-tumor efficacy in the pre-clinical study, including completed response observed in the mouse tumor model.
“We are pleased to have completed the first patient dosing of B7H4x4-1BB in the U.S., marking another milestone to lead next-gen immuno-oncology therapeutics innovation in global market. Following our global innovation and development strategy, Harbour BioMed will advance the global clinical development project of HBM7008 at full speed to provide a novel, effective and safe treatment for patients.” said Dr. Jingsong Wang, Founder, Chairman and CEO of Harbour BioMed.
About HBM7008
HBM7008 is a bispecific antibody targeting Tumor Associated Antigen B7H4x4-1BB that not only displays high potency in the T cell co-stimulation and tumor growth inhibition, and potentially may also translate to better safety due to its strict dependency of TAA-mediated crosslinking T cell activation
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