eClinical Technology and Industy News

Nektar and Collaborators Announce Publication in Blood Advances of Preclinical Data Demonstrating NKTR-255, a Novel Polymer-conjugated Human IL-15, Improves Efficacy of CD19-targeted CAR-T Cell Immunotherapy

— Polymer-conjugated IL-15 (NKTR-255) induced CD8+ T cell and natural killer cell proliferation in vivo

— NKTR-255 enhanced the efficacy of human CD19 CAR-T cells in a xenogeneic lymphoma model —

Excerpt from the Press Release:

SAN FRANCISCO, Nov. 9, 2022 /PRNewswire/ — Nektar Therapeutics (Nasdaq: NKTR) today announced the publication of preclinical data in Blood Advances, the open-access journal of the American Society of Hematology, highlighting the effects of NKTR-255, a novel polymer-conjugated human IL-15, on the efficacy of human CD19 CAR-T cells in a xenogeneic lymphoma model and on CD8+ T effector cell (Tcell) and natural killer (NK) cell proliferation in non-human primates.

“The findings published today reinforce the foundational rationale behind the clinical development program we’re pursuing of NKTR-255 enhancing CAR-T cell therapies,” said Jonathan Zalevsky, Ph.D., Chief Research & Development Officer at Nektar. “We are looking forward to progressing our research in combination with cell therapies and are excited to launch our Phase 2/3 clinical trial of NKTR-255 following approved CAR-T cell therapies in patients with relapsed or refractory diffuse large B-cell Lymphoma.”

The data from this publication demonstrate that NKTR-255 not only enhanced in vivo proliferation and accumulation of T and NK cells in non-human primates, but also demonstrated enhanced in vivo antitumor efficacy of human CD19 CAR-T in lymphoma-bearing immunodeficient mice.

Click the button below to read the entire Press Release:

Continue Reading The Press Release

Discover What Sets TrialStat Apart From Ordinary EDC Platforms

Click the image or button below to explore our eClinical Suite Platform and discover what sets TrialStat apart from competing EDC platforms.

Request Your Demo Today!

From rapid database build through database lock, we deliver consistent quality on-time and on-budget. Ready to upgrade your eClinical toolkit?