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Nutcracker Therapeutics Demonstrates Enhanced Activity of B Cell Lymphoma Candidate NTX-472 at the 2024 ASCO Annual Meeting

  • Multispecific antibody encoded by NTX-472 preferentially engaged CD47 in presence of co-engagement of CD20 and CD19
  • One dose of NTX-472 in vivo rapidly depleted B cells with no detectable binding to red blood cells

Excerpt from the Press Release:

EMERYVILLE, Calif.–(BUSINESS WIRE)–Nutcracker Therapeutics, Inc., a biotechnology company dedicated to developing transformative RNA therapies through its proprietary technology platform, recently presented a poster on NTX-472, its new preclinical drug candidate for B cell lymphoma, at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Monoclonal antibody immunotherapies can provide an effective treatment for B cell lymphoma. However, by only targeting a single tumor antigen, such as CD19 or CD20, these treatments can place selective pressures on tumors, with cancer cells often down-regulating the expression of those specific antigens to become cold tumors, invisible to the immune system. Multispecific antibodies may be able to mitigate these effects with improved specificity to several antigens at once.

Nutcracker Therapeutics’ scientists engineered a panel of molecules simultaneously targeting CD20, CD19 and CD47 to compare them to existing monoclonal antibody immunotherapies for B cell lymphoma, including rituximab (monospecific anti-CD20) and tafasitamab (monospecific anti-CD19). Of these molecules, the team identified one which had improved tumor killing and B cell depletion in vitro, which became the NTX-472 program.

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