Acumen Pharmaceuticals Presents Studies Showing the Utility of a pTau217 Assay in Screening for a Phase 2 Alzheimer’s Disease Trial and Validates Sabirnetug Oligomer-Selectivity, at the Alzheimer’s Association International Conference (AAIC) 2025
Excerpt from the Press Release:
NEWTON, Mass., July 28, 2025 (GLOBE NEWSWIRE) — Acumen Pharmaceuticals, Inc. (NASDAQ: ABOS), a clinical-stage biopharmaceutical company developing a novel therapeutic that targets soluble amyloid beta oligomers (AβOs) for the treatment of Alzheimer’s disease (AD), today announced results showing that implementing a blood-based pTau217 screening assay reduced Acumen’s overall clinical trial screening costs by approximately 40% in its Phase 2 ALTITUDE-AD study of sabirnetug in early Alzheimer’s disease in the U.S. and Canada. Additionally, a nonclinical study revealed sabirnetug achieved the highest selectivity for AβOs over Aβ monomers relative to recombinant lecanemab and aducanumab. The results are being presented at the Alzheimer’s Association International Conference (AAIC), taking place July 27-31, 2025, in Toronto and online.
“These advances represent important progress in addressing the critical need for effective treatments targeting toxic amyloid β oligomers (AβOs) in early symptomatic Alzheimer’s disease, while simultaneously demonstrating patient-centric and cost-effective trial execution strategies,” said Eric Siemers, M.D., Chief Medical Officer of Acumen Pharmaceuticals. “By combining cutting-edge therapeutic development with smart clinical trial strategies, we’re working to create a more efficient path forward in bringing potential new options to patients with Alzheimer’s disease. “
ALTITUDE-AD: Cost savings using a pTau217 screening assay in an ongoing Phase 2 study of sabirnetug in early Alzheimer’s disease
Acumen reported operational innovations in its ALTITUDE-AD Phase 2 clinical trial where researchers implemented an innovative two-step screening process using plasma pTau217 biomarker assay testing that yielded significant clinical trial screening and cost efficiencies. The approach reduced total screening costs by approximately 40% across U.S. and Canadian sites.
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