Kymera Therapeutics Completes Enrollment in the Phase 2b BROADEN2 Trial of KT-621 in Atopic Dermatitis with Topline Data by Year-end 2026
BROADEN2 enrollment completed nearly six months ahead of anticipated timelines
KT-621 Phase 3 trials in AD planned to initiate by mid-2027
KT-621 BREADTH Phase 2b asthma trial ongoing, with data expected to be reported in late 2027
Excerpt from the Press Release:
WATERTOWN, Mass., June 25, 2026 (GLOBE NEWSWIRE) — Kymera Therapeutics, Inc. (NASDAQ: KYMR), a clinical-stage biopharmaceutical company advancing a new class of oral small molecule degrader medicines for immunological diseases, today announced it has completed enrollment in the global BROADEN2 Phase 2b trial of KT-621, its first-in-class, oral STAT6 degrader, for the treatment of moderate to severe atopic dermatitis (AD). The earlier than expected completion of enrollment enables Kymera to accelerate its expected topline data readout by six months to year-end 2026, earlier than prior guidance to share data by mid-2027. Subject to discussions with regulators, the Company expects to initiate Phase 3 trials in AD by mid-2027.
“Completing enrollment in BROADEN2 nearly six months ahead of our anticipated timeline reflects a high degree of patient and provider interest in a safe and effective oral option for atopic dermatitis, a chronic and debilitating disease. It’s also a testament to KT-621’s compelling profile across preclinical, healthy volunteer, and patient studies, and the best-in-industry execution of our team,” said Nello Mainolfi, PhD, Founder, President and CEO, Kymera Therapeutics. “With enrollment now complete, we are positioned to bring forward our expected topline data readout to this year as well as accelerate our planned Phase 3 initiation, subsequent readouts, and NDA filing.”
BROADEN2 is a global, randomized, double-blind, placebo-controlled, dose-ranging study evaluating the efficacy, safety, and tolerability of three doses of KT-621 in approximately 200 adult and adolescent patients, ages 12 to 75, with moderate to severe AD over 16 weeks. The primary endpoint is the percent change from baseline in Eczema Area and Severity Index (EASI) score at Week 16.
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