Frontier Medicines Advances First Development Candidate, FMC-376, a Uniquely Differentiated Inhibitor of Both Active and Inactive KRASG12C, into IND-Enabling Studies
FMC-376 directly, rapidly, and completely blocks both active and inactive forms of KRASG12C to overcome non-response and resistance seen with prior generation KRASG12C inhibitors
The company has also advanced two additional precision oncology programs against historically undruggable disease-causing targets into lead optimization
Pamela Klein, M.D., seasoned oncology drug developer, elected to board of directors
Excerpt from the Press Release:
SOUTH SAN FRANCISCO, Calif. and BOSTON, Jan. 05, 2023 (GLOBE NEWSWIRE) — Frontier Medicines Corporation, a precision medicine company advancing transformative drugs against historically undruggable disease-causing targets, announced the selection of its first development candidate, FMC-376, an oral, covalent small-molecule inhibitor that selectively targets both active (GTP-bound) and inactive (GDP-bound) conformations of KRASG12C. In preclinical studies, FMC-376 retains potency in the context of receptor tyrosine kinase activation, which is likely a major mechanism of non-response and resistance to prior generation inhibitors that only target inactive (GDP-bound) KRASG12C. Preclinical data for FMC-376 supports a potential best-in-class profile for safety and efficacy, with the promise of first-line treatment in both monotherapy and combination use. IND filing for FMC-376 is planned for this year.
“We founded Frontier to bring breakthrough medicines to patients, and we are proud to introduce FMC-376, which has demonstrated tremendous preclinical efficacy and safety, as our first development candidate,” said Chris Varma, Ph.D., Frontier’s co-founder, chairman, and CEO. “We continue to be impressed with the differentiating properties of FMC-376, and we look forward to exploring FMC-376’s full potential in the clinic to help patients with high unmet need.”
FMC-376 was discovered through the Frontier™ Platform, which brings together proprietary chemoproteomic and AI technologies with a custom-built covalent library and Druggability Atlas™ of the proteome. The Frontier™ Platform enables breakthrough covalent small-molecule drugs against historically ‘undruggable’ targets.
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