Ufovax Announces Its Self-Assembling NanoParticles as the Next-Generation Vaccine Solution for COVID-19

Excerpt from the Press Release:

WILMINGTON, Del.–(BUSINESS WIRE)–Ufovax, LLC, (Ufovax), a vaccine biotechnology company based on the patented One-component Self-Assembling protein NanoParticle® (1c-SApNP®) vaccine design and manufacturing platform invented by Associate Professor Jiang Zhu, PhD, of Scripps Research (La Jolla, CA), announced the advancement toward Phase I clinical trials of its next-generation SARS-CoV-2 (aka “COVID-19”) vaccine candidate. Ufovax holds an exclusive global license to the Scripps Intellectual Property covering the platform and several vaccines, including COVID-19.

In a publication submitted Monday, September 14 (now available on the bioRxiv preprint server), the authors present a systematic study on rational vaccine design and evaluation of vaccine response in mice. In particular, Zhu and his team propose a new spike antigen design (S2GΔHR2) and displayed it on several SApNPs as COVID-19 vaccine candidates. This spike is missing the highly flexible heptad repeat 2 (HR2) stalk which, as recently reported in several independent publications, is considered a major cause of spike metastability. This metastability is the mechanism responsible for masking the COVID-19 spike from immune recognition and allowing very efficient human infection.

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