Adagio Therapeutics COVID-19 Antibody Demonstrates Best-in-Class Breadth and Potency Against a Range of Coronaviruses that Pose Human Threat

Excerpt from the Press Release:

WALTHAM, Mass.–(BUSINESS WIRE)–Adagio Therapeutics, Inc., today pre-published in vitro and in vivo data demonstrating its lead antibody candidate, ADG2, shows similar or higher potency against SARS-CoV-2 compared to monoclonal antibodies (mAbs) in clinical development, while also uniquely offering broad neutralization against a range of sarbecoviruses that pose a threat to humans. Adagio expects its half-life engineered version of ADG2, called ADG20, to enter clinical studies in early 2021. The manuscript summarizing the Adagio findings has been accepted for review by the journal Science and was made available on the bioRxiv.org pre-print server.

“These studies demonstrate our lead antibody shows comparable or higher neutralization potency against SARS-CoV-2 than most leading antibodies currently in development for COVID-19, and yet maintains its ability to potently neutralize SARS-CoV and additional pre-emergent SARS-like coronaviruses currently circulating in bats,” said Laura Walker, Ph.D., chief scientific officer of Adagio. “All of the antibodies currently in clinical development trade-off breadth for potency. They either show broad activity against other sarbecoviruses but lack neutralization potency, or they show high neutralization potency against SARS-CoV-2 but lack activity against other coronaviruses. These data suggest that ADG20 holds the promise of being a broadly protective agent against SARS-CoV-2 as well as future SARS-like coronaviruses that are likely to emerge.”

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