Vivace Therapeutics announces dosing of first cohort of patients with its first-in-class TEAD inhibitor

Excerpt from the Press Release:

SAN MATEO, Calif., May 4, 2021 /PRNewswire/ — Vivace Therapeutics, Inc., a small molecule discovery and development company developing first-in-class therapies targeting the Hippo pathway, announced today the completion of enrollment of the first cohort of patients being treated with VT3989 in its Phase 1 clinical study. The Company anticipates enrolling the next higher dose cohort in the second part of May.  

The VT3989 Phase 1 study is now open at centers in both the US and Australia (https://clinicaltrials.gov/ct2/show/NCT04665206) to evaluate the safety, tolerability, PK and biological activity of VT3989 in patients with refractory metastatic solid tumors, including refractory pleural malignant mesothelioma. The study is currently in dose escalation, to be followed by a dose expansion phase in which patients with NF2 mutant tumors will be enrolled after an optimal dose is determined. “To the best of our knowledge, we are the first company to test a small molecule in the clinic targeting this important pathway. Our preclinical work has shown that tumors with NF2 mutations are quite sensitive to VT3989, especially NF2-deficient mesothelioma,” said Leonard Post, Ph.D., Chief Scientific Officer of Vivace Therapeutics.

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