Acepodia Publishes Preclinical Data on Novel Off-the-Shelf Natural Killer Cell Therapy, ACE1702, for HER2-Expressing Solid Tumors Using Antibody-Cell Conjugation Technology in the Journal Cancers

Excerpt from the Press Release:

SAN MATEO, Calif., June 07, 2021 (GLOBE NEWSWIRE) — Acepodia, a biotechnology company developing next generation solid tumor and hematologic cancer cell therapies, today announced that an article describing the efficacy profile of ACE1702, Acepodia’s novel, off-the-shelf natural killer (NK) cell therapy against HER2-expressing solid tumors, was published in the journal Cancers. The article, titled “A Novel off-the-Shelf Trastuzumab-Armed NK Cell Therapy (ACE1702) Using Antibody-Cell-Conjugation Technology,” is available on the Acepodia corporate website at Acepodia.com/newsroom/publications.

In the study, the Company applied its antibody-cell conjugation (ACC) platform to conjugate its oNK cells, which are a unique line of proprietary off-the-shelf NK cells, with an anti-human epidermal growth factor receptor 2 (HER2) antibody trastuzumab. Trastuzumab-conjugated oNK demonstrated its in vitro and in vivo cytotoxicity against HER2-expressing cancer cells and secretion of interferon gamma (IFNγ). Irradiated and cryopreserved trastuzumab-conjugated oNK (ACE1702) retained HER2-specific in vitro and in vivo potency with no tumorigenic potential.

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