Data from a Phase I study of RM-1929 Photoimmunotherapy in Japanese Patients with Recurrent Head and Neck Squamous Cell Carcinoma was Published in the International Journal of Clinical Oncology
Excerpt from the Press Release:
SAN MATEO, Calif., July 8, 2021 /PRNewswire/ — Rakuten Medical, Inc. (Rakuten Medical) announced that data from a phase I, single-center, open-label study of RM-1929 photoimmunotherapy in Japanese patients with recurrent head and neck squamous cell carcinoma (rHNSCC) was accepted for publication in the International Journal of Clinical Oncology and published on June 24, 2021.
The manuscript describes the design of a Phase I study, where patients were given a single fixed dose (640 mg/m²) of RM-1929, an anti-EGFR antibody cetuximab conjugated with a light-activatable dye (IRDye®700DX), and a fixed light treatment dose (50 J/cm² for superficial illumination; 100 J/cm fiber diffuser length for interstitial illumination) in Japan. The study was designed to evaluate the safety, tumor response (modified RECIST v1.1 by central radiology review), pharmacokinetics, and immunogenicity administered in subjects with rHNSCC.
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