Rubius Therapeutics: Publication of RTX-240 Preclinical Data in Cancer Immunology, Immunotherapy

Excerpt from the Press Release:

CAMBRIDGE, Mass., July 15, 2021 (GLOBE NEWSWIRE) — Rubius Therapeutics, Inc. (Nasdaq:RUBY), a clinical-stage biopharmaceutical company that is genetically engineering red blood cells to create an entirely new class of cellular medicines called Red Cell Therapeutics™, today announced the publication of preclinical data in the peer-reviewed journal Cancer Immunology, Immunotherapy, for its lead clinical oncology program, RTX-240, for the treatment of adults with advanced solid tumors and relapsed/refractory acute myeloid leukemia.

The paper entitled “Anti-Tumor Effects of RTX-240: an Engineered Red Blood Cell Expressing 4-1BB Ligand and Interleukin-15” highlights preclinical findings, which demonstrate that RTX-240 activates and expands CD8+ T cells and NK cells in vitro and in vivo generating potent anti-tumor activity in both a colorectal and melanoma model. The paper is available here: https://doi.org/10.1007/s00262-021-03001-7.

“These preclinical data demonstrate RTX-240’s mechanism of action, which we’ve also seen translated to the clinic thus far. Namely, in these preclinical models, RTX-240 activated and expanded both NK and T cells capable of trafficking to the tumor and killing tumor cells, while showing only minimal toxicity due to the biodistribution of RTX-240 to the vasculature and spleen,” said Laurence Turka, M.D., chief scientific officer of Rubius Therapeutics. “Compared to a 4-1BB agonist antibody, RTX-240 was better tolerated and demonstrated a wider therapeutic window in preclinical studies, suggesting that RTX-240 could provide a more efficacious and safer option for the treatment of patients with advanced solid tumors and acute myeloid leukemia.”

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