Indapta Therapeutics Announces New Preclinical Data Demonstrating Proprietary G-NK Cells Enhance Efficacy of Monoclonal Antibodies in Multiple Myeloma

Excerpt from the Press Release:

SAN FRANCISCO–(BUSINESS WIRE)–Indapta Therapeutics, Inc., a biotechnology company developing and commercializing an NK (natural killer) cell therapy platform for the treatment of blood cancers and solid tumors, today announced the publication of new preclinical data in Blood Advances demonstrating Indapta’s proprietary allogeneic FcεRIγ-deficient G-NK cells in combination with an FDA-approved monoclonal antibody (mAb) resulted in greater than 99.9% tumor reduction in a preclinical cancer regression model of multiple myeloma compared to conventional NK cells. G-NK cells are a naturally occurring subset of NK cells that when expanded and “turbocharged” using Indapta’s proprietary manufacturing process, boost the efficacy of mAbs and can overcome the cost, inconsistency, and possible toxicities associated with autologous T-cell therapies commonly used in the treatment of multiple myeloma.

“These results suggest Indapta’s G-NK cells have the potential to be a potent off-the-shelf NK cell therapy that could enhance the efficacy of most mAbs,” said Guy DiPierro, founder and chief executive officer of Indapta. “The promising results showed G-NK cells, compared to conventional NK cells, significantly enhanced anti-tumor cell activity of two FDA-approved mAbs for multiple myeloma and were able to maintain this augmented activity, expand in vivo, and have greater persistence even after cryopreservation. Together with a simplified and consistent, high-yield commercial-scale manufacturing platform at Lonza, we have the potential to produce an NK cell therapy with outstanding efficacy at a lower cost than other engineered cell therapies.”

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