Spike Protein’s RBD Leaps Out of the Gate
Excerpt from the Press Release:
If you thought you were familiar with the SARS-CoV-2 spike protein, think again. According to a new study, the spike protein has a secret feature—a starting gate. It consists of glycans. When the gate is closed, the spike protein’s receptor binding domain (RBD) stays hidden, safe from the prying eyes of the immune system. When the gate is open, out leaps the RBD.
At this point, the starting gate analogy breaks down. The RBD is no thoroughbred. It doesn’t have to be. The race to the host receptor is too short.
That last observation suggests that it might be hard to rein in RBD, once it is in the running. So, it might be best to keep the starting gate closed. In fact, this possibility was raised in the new study, which was led by Rommie Amaro, PhD, professor of chemistry and biochemistry at the University of California, San Diego (UCSD), and Lillian Chong, PhD, associate professor of biophysics at the University of Pittsburgh.
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