eClinical Technology and Industy News

Elicio Therapeutics Presents Updated Preclinical Data at the 2021 Vaccines Summit Demonstrating that ELI-005, a Lymph Node Targeted Amphiphile Vaccine, Induces Potent Cellular and Humoral Immunity to SARS-CoV-2

  • ELI-005, containing the Amphiphile vaccine adjuvant AMP-CpG, induced >25-fold higher antigen-specific T cells in the peripheral blood and exhibited potent killing of antigen-positive targets in vivo that were maintained for >5 months after vaccination
  • Vaccine responses were highly cross-reactive to SARS-CoV-2 variants of concern
  • Antibody responses favored TH1 isotypes with titers 265-fold higher than natural convalescent patient COVID-19 responses
  • Results suggest delivery of AMP-CpG to lymph nodes could be applied to rapid development of prophylactic or therapeutic vaccine candidates targeting a variety of disease-specific antigens

CAMBRIDGE Mass., Sept. 22, 2021 (GLOBE NEWSWIRE) — Elicio Therapeutics, a clinical-stage biotechnology company developing a pipeline of novel immunotherapies for the treatment of cancer and other diseases, today announced positive preclinical data demonstrating that ELI-005, a protein subunit vaccine containing the lymph node-targeted Amphiphile-CpG adjuvant (AMP-CpG), induces potent cellular and humoral immunity to SARS-CoV-2 at the 2021 Vaccines Summit, being held virtually on September 20-22, 2021.

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