Phio Pharmaceuticals Presents Data at ESMO 2021 Demonstrating Persistent Anti-Tumor Immunity with INTASYL Dual-Targeting PD-1 and BRD4
Local treatment with PD-1 and BRD4 dual-targeting INTASYL also showed complete resolution of tumors in vivo
Excerpt from the Press Release:
MARLBOROUGH, Mass., Sept. 16, 2021 /PRNewswire/ — Phio Pharmaceuticals Corp. (Nasdaq: PHIO), a biotechnology company developing the next generation of immuno-oncology therapeutics based on its proprietary self-delivering RNAi (INTASYL™) therapeutic platform, today announced results of a new study showing that local treatment in vivo with INTASYL can cure tumors and generate systemic tumor immunity that is both durable and tumor specific. These data, which were presented at the European Society of Medical Oncology (ESMO) Congress 2021, highlight the potential of the Company’s INTASYL technology in direct therapeutic applications.
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The study was performed to show the synergistic activity of co-targeting PD-1 and BRD4 with one INTASYL formulation (PH-3861) in a preclinical in vivo hepatocellular carcinoma model. The results show that up to 83% of the animals treated with PH-3861 had a complete response when treated at low doses, namely doses suboptimal for monotherapy. Moreover, this treatment induced a durable and specific systemic anti-tumor immune response, without requiring further treatment.
“We continue to build on data presented earlier this year and show how our INTASYL technology can be utilized in various applications to treat cancer, including its broad applicability as a direct therapeutic. Since cancer is a multifactorial disease, being able to address multiple factors at once is a significant benefit. The data presented today at the ESMO Congress demonstrate that we can target multiple genes in one INTASYL product, resulting in powerful therapeutics showing complete resolution of tumors and generation of tumor-specific immunity that persists for months after the initial treatment,” said Dr. Simon Fricker, Phio’s Vice President of R&D. “We look forward to further validate INTASYL as a therapeutic modality in an upcoming clinical trial with our lead INTASYL product candidate.”
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