Jacobio JAB-21822 in Combination with Cetuximab Completes First Dose of Colorectal Cancer Patient in China
Excerpt from the Press Release:
BEIJING, SHANGHAI and BOSTON, Feb. 23, 2022 /PRNewswire/ — Jacobio Pharmaceuticals (1167.HK) announced that its KRAS G12C inhibitor JAB-21822 completed the first patient dosing in combination therapy with Cetuximab at Peking University Cancer Hospital recently.
JAB-21822 in combination with cetuximab for the treatment of KRAS G12C-mutated advanced colorectal cancer. Colorectal cancer is the second most common tumor in China, with about 550,000 new cases per year, of which about 3% of colorectal cancer patients have KRAS G12C mutation. Patients with KRAS G12C mutation are insensitive to existing standard chemotherapies and targeted therapies, have rapid disease progression, short survival, and have high unmet clinical treatment needs.
JAB-21822 is the first KRAS G12C inhibitor in China to be combined with cetuximab. This combination trial’s principle investigator is Professor Lin SHEN, vice president of Peking University Cancer Hospital and director of the Department of Gastrointestinal Oncology. Professor Lin SHEN said,”According to global clinical trials of KRAS G12C inhibitors, it has shown preliminary efficacy in patients with colorectal cancer. Jacobio’s JAB-21822 has progressed rapidly since it submitted IND (Investigational New Drug) application for combination therapy with Cetuximab to CDE (Center for Drug Evaluation, NMPA) in August 2021, and JAB-21822 is the fastest-developing clinical project among same class drug. We will work closely with the Jacobio team, we hope this drug will soon become a new treatment option for patients with advanced colorectal cancer.”
“JAB-21822 has the potential to be best-in-class KRAS G12C inhibitor for its high activity and dose advantages, and it’s expected to improve patients’ medication compliance and quality of life,” said Dr. Yinxiang WANG, Chairman and CEO of Jacobio.
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