Catalys Pacific Launches Kirilys Therapeutics as a Multi-asset Precision Oncology Company
Excerpt from the Press Release:
SAN FRANCISCO–(BUSINESS WIRE)–Kirilys Therapeutics, Inc., a private, preclinical-stage biopharmaceutical company founded by investment firm Catalys Pacific, announced today that the Company completed a seed financing led by Lightspeed Venture Partners. The company licensed its lead compound, KRLS-017, from Ube Industries, Ltd., a premier Japanese chemical manufacturer. The company also completed a partnership agreement with D2G Oncology, Inc. which uses genetically defined animal tumor models to reveal relationships between cancer genotypes and drug efficacy. This financing round will enable Kirilys to complete all activities through the IND filing of KRLS-017, as well as preparatory work for the Phase 1 clinical development program.
KRLS-017 is a reversible small molecule inhibitor of Cyclin Dependent Kinase 7 (CDK7). CDK7 has been implicated as a key regulator of both transcriptional addiction and cell cycle dysregulation in tumors and therefore represents an attractive target for therapeutic intervention across a broad range of solid tumors and hematologic malignancies. In preclinical studies, KRLS-017 demonstrated best-in-class potency, selectivity, and anti-tumor efficacy along with very favorable properties for an oral drug.
“Selective inhibition of CDK7 offers a compelling opportunity to bring new therapeutic options to patients suffering from difficult to treat transcriptionally-driven cancers,” said Galym Imanbayev, M.D., partner at Lightspeed Venture Partners. “We are excited to back this unique combination of accomplished team, quality of asset, and a proprietary clinical strategy enabled by D2G Oncology.”
“We founded Kirilys to combine ground-breaking science in precision oncology from D2G Oncology with excellent drug discovery from Japan,” said BT Slingsby, M.D., Ph.D., M.P.H., founder and executive chairman of Kirilys and managing partner, Catalys Pacific. “KRLS-017 holds significant potential for patients worldwide and we are confident in the tremendously experienced Kirilys team to develop KRLS-017 and deliver on that promise.”
Click the button below to read the entire Press Release:
Discover What Sets TrialStat Apart From Ordinary EDC Platforms
Click the image or button below to explore our eClinical Suite Platform and discover what sets TrialStat apart from competing EDC platforms.
Request Your Demo Today!
From rapid database build through database lock, we deliver consistent quality on-time and on-budget. Ready to upgrade your eClinical toolkit?