Foghorn Therapeutics Presents New Preclinical Data on Novel BRG1/BRM Inhibitor FHD-286 at the 2022 AACR Annual Meeting

Excerpt from the Press Release:

CAMBRIDGE, Mass., April 13, 2022 (GLOBE NEWSWIRE) — Foghorn^® Therapeutics Inc. (Nasdaq: FHTX), a company pioneering the discovery and development of a new class of medicines targeting genetically determined dependencies within the chromatin regulatory system, today announced preclinical data supporting the clinical development and mechanistic understanding of BAF inhibition through the BRG1 (SMARCA4) and BRM (SMARCA2) dual inhibitor, FHD-286, for the treatment of cancer, at the 2022 American Association for Cancer Research (AACR) Annual Meeting in New Orleans, Louisiana. FHD-286 has first-in-class potential and is Foghorn’s first candidate directly targeting the chromatin regulatory system to emerge from the Company’s Gene Traffic Control® platform. With an initial focus in oncology, Foghorn’s Gene Traffic Control^® Platform and resulting broad pipeline has the potential to transform the lives of people suffering from a wide spectrum of diseases.

“We were pleased to present preclinical data at AACR this year, supporting the mechanistic understanding of FHD-286’s anti-tumor activity in AML through the hematopoietic transcriptional regulator SPI1,” said Steve Bellon, Chief Scientific Officer. “We are highly encouraged by the broad, pre-clinical therapeutic data supporting clinical development of FHD-286, demonstrated by tumor inhibition in different cancer cell types, synergistic activity with combination partners, including chemotherapy or targeted therapies, and mutation agnostic responses in AML patient derived bone marrow samples.”

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