Alcresta Therapeutics Announces Preclinical Data Showing ALC-078 Cartridge Use in SBS Model Was Associated with Improved Fat and Nutrient Absorption
Preclinical data published in Journal of Clinical Nutrition highlight potential applications of ALC-078 cartridge in short bowel syndrome nutrition management
Excerpt from the Press Release:
NEWTON, Mass. , April 27, 2022 /PRNewswire/ — Alcresta Therapeutics, Inc., a leading commercial-stage company focused on developing and commercializing novel enzyme-based products, today announced publication of preclinical data from the company’s development device, ALC-078, in a porcine short bowel syndrome (SBS) model. Results from the study conducted at Boston Children’s Hospital showed that the treatment with ALC-078 was associated with improvements in fat and nutrient absorption.
“ALC-078 is being developed as an iteration of RELiZORB® that could expand the utility of this innovative device for use with a broader range of enteral formulas, including those specific to SBS, while also expanding the potential for use in bolus feeding, which is a common enteral feeding approach in SBS patients who often exceed 1000mL of formula per day,” said Greta Loring, VP of Research and Development at Alcresta.
The study assessed the use of a novel enteral feeding porcine SBS model in addressing a gap in data regarding the management of enterally fed SBS piglets weaned off parenteral nutrition (PN). SBS piglets gain less weight, develop fat malabsorption, and demonstrate a decrease in fat-soluble vitamin concentrations, representing important clinical sequelae in the pediatric and adult SBS populations not previously shown in other preclinical studies. Patients with SBS who are weaned off PN still experience sequelae of the disease (e.g., need for intravenous fluid supplementation and worsening nutritional deficiencies), which further highlights the importance of utilizing porcine SBS models without PN support to encompass the wide clinical spectrum of SBS. The three-arm study compared non-resected normal control, 75% bowel resected, and 75% bowel resected piglets treated with ALC-078.
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