Bicara Therapeutics Presents Data from Dose Escalation Portion of Ongoing Phase 1/1b Trial of Lead Bifunctional Program, BCA101, at the American Society of Clinical Oncology 2022 Annual Meeting
- Durable responses achieved in highly refractory patients as monotherapy (one patient with relapsed squamous cell lung cancer) and in combination with pembrolizumab (several subjects with relapsed squamous cell carcinoma of the anal canal and head and neck squamous cell carcinoma)
- Dose escalation portion of the study has completed and recommended dose declared, as monotherapy and in combination with pembrolizumab
- BCA101 has a manageable safety profile, a predictable PK and peripheral and tumor PD markers that support mechanisms of action
Excerpt from the Press Release:
CAMBRIDGE, Mass.–(BUSINESS WIRE)–Bicara Therapeutics, a clinical-stage biotechnology company developing dual-action biologics designed to modulate the tumor microenvironment to elicit a potent and durable anti-tumor response, today announced the presentation of new clinical data on BCA101, a bifunctional antibody designed to target the TGF-β trap to EGFR+ tumors. Data from the dose escalation phase of the ongoing Phase 1/1b trial of BCA101 as a monotherapy and in combination with the immune checkpoint inhibitor pembrolizumab will be presented in a poster discussion session at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, IL.
“We observed durable responses across three different indications in a heavily pretreated and advanced cancer population, including a partial response in one patient with relapsed squamous cell lung cancer who was treated with BCA101 as monotherapy. Additionally, observed biomarkers support the mechanisms of action for BCA101 and demonstrate clear remodeling of the tumor microenvironment,” said Liviu Niculescu, M.D., Chief Medical Officer of Bicara Therapeutics. “The findings from the dose escalation phase of the ongoing Phase 1/1b trial are compelling and support our view that BCA101 offers a potentially more efficacious and durable treatment option for patients with several types of solid tumors, particularly in combination with other
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