Rune Labs Partners with Coastal Research Institute to Identify Biomarkers of Multiple Sclerosis Lesions using AI Platform to Analyze Patient Neurophysiological Data

Quantitative biomarkers of demyelination can improve clinical trial design and accelerate development of disease-modifying therapeutics

Excerpt from the Press Release:

SAN FRANCISCO, July 14, 2022 /PRNewswire/ — Rune Labs, a precision neurology software and data platform company, today announced it is enrolling patients with multiple sclerosis (MS) in a study to identify neurophysiological biomarkers of the disease. The company has partnered with Coastal Research Institute (CRI) to measure demyelination in patients with spinal cord stimulators using closed loop technology. Demyelination is a hallmark symptom of MS that occurs when the immune system attacks nerve fibers, causing lesions in the brain and spine. 

More remyelination therapeutics are entering the clinic, but there are no biomarkers that measure a patient’s degree of myelination, making it difficult to assess a drug’s efficacy. Clinical scores currently used as endpoints and screeners in trials are imprecise and do not always correlate with lesion activity. Other approaches like imaging and measuring optic nerve electrophysiology only apply to a subset of patients with specific symptoms.

“By taking advantage of access to the spinal cord provided during routine clinical procedures, this study will capture precise neurophysiological data and measure myelination using a variety of evoked potentials,” said Ro’ee Gilron, Rune Labs’ lead neuroscientist. “Rune’s AI platform enables us to take raw brain data and convert it into actionable biomarkers of myelination.”

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