Elicio Therapeutics Announces Publication of Preclinical Data on ELI-005, a Lymph Node-Targeted Amphiphile Vaccine Against SARS-CoV-2

• Data published in bioRxiv shows ELI-005 administration safely promotes robust cellular and humoral immunity through potent and targeted engagement of the lymph nodes in mice and non-human primates (NHPs)
• Prime-boost administration of ELI-005 induced potent Spike receptor binding domain (RBD)-specific effector cytokine-producing T cell responses in mouse and NHP peripheral blood showing cross-reactivity against variants of concern
• Antibody neutralizing activity from vaccinated NHPs was specific for multiple viral variants of concern, including Omicron, at levels ~10-fold increased relative to levels in convalescent human patients
• In mice, AMP-CpG induced increased numbers of innate immune cells expressing co-stimulatory molecules and producing key cytokines, correlated with significant increases in lymph node inflammatory proteomic and transcriptomic signatures

Excerpt from the Press Release:

BOSTON, Sept. 07, 2022 (GLOBE NEWSWIRE) —  Elicio Therapeutics, a clinical-stage biotechnology company developing a pipeline of novel immunotherapies for the treatment of cancer and other diseases, today announced the publication of data from a preclinical study evaluating ELI-005, Elicio’s Amphiphile (AMP) adjuvant, AMP-CpG, admixed with the SARS-CoV-2 Spike receptor binding domain (RBD) immunogen, as a lymph node-targeted protein subunit vaccine. The results show ELI-005 administration safely promotes robust cellular and humoral immunity through potent, targeted engagement of the lymph nodes in both mice and non-human primates (NHPs). Additionally, these data demonstrate the promise of lymph node adjuvant-targeting to coordinate innate immunity and the generation of robust adaptive responses that are critical for vaccine efficacy. These results were published in the preprint server, bioRxiv, and can be accessed here.

“We are thrilled to see robust and persistent responses across several SARS-CoV-2 variants of concern with our lymph node-targeted protein subunit vaccine, ELI-005, in preclinical models predictive of human immunity,” said Robert Connelly, Chief Executive Officer at Elicio. “These data build on what we are seeing in all of our ongoing preclinical and clinical programs in oncology and infectious diseases, demonstrating the ability of our AMP platform to efficiently deliver immunotherapeutics directly to the lymph node eliciting potent immune responses.”

Although currently authorized vaccines have shown success in the reduction of severe disease risk from COVID-19, rapidly emerging viral variants continue to drive substantial pandemic waves of infection, resulting in numerous global public health challenges. Future advances in prophylactic vaccine activity will play a critical role in the resolution of these challenges as will the advancement of candidates capable of generating more potent induction of cross-reactive T cells and durable cross-reactive antibody responses. In the absence of sterilizing immunity, robust memory B and cross-reactive T cell responses that are capable of rapid re-activation could provide effective long-term protection against the worst outcomes of disease. The spike RBD domain plays an important role in promoting neutralizing antibody responses to SARS-CoV-2 in the immune system. The robust immune responses generated by ELI-005 suggest that it may enhance broad protection against new variants of concern.

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