Q32 Bio and Horizon Therapeutics plc Announce Dosing of First Patient in Phase 2 Trial of ADX-914 for Atopic Dermatitis

Excerpt from the Press Release:

WALTHAM, Mass. and DUBLIN, Oct. 27, 2022 /PRNewswire/ — Q32 Bio, a clinical stage biotechnology company developing biologic therapeutics to restore immune homeostasis, and Horizon Therapeutics plc (Nasdaq: HZNP), today announced that the first patient has been dosed in a randomized, double-blind, placebo-controlled, Phase 2 multi-center proof-of-concept study in adult subjects to evaluate the safety and efficacy of ADX-914 in persistent, moderate-to-severe atopic dermatitis (AD). Q32 Bio and Horizon are developing ADX-914, a fully human anti-IL-7Rα antibody that re-regulates adaptive immune function, in collaboration.

“The dosing of the first patient in our Phase 2 trial of ADX-914 is an important milestone for both companies that underscores our commitment to delivering novel, disease-modifying treatments to individuals with autoimmune and inflammatory diseases,” said Jodie Morrison, Board Member and Acting Chief Executive Officer of Q32 Bio. “We appreciate our close collaboration with Horizon as we advance ADX-914 in the clinic.”  

“We are excited to advance the development of ADX-914 in patients suffering from moderate to severe atopic dermatitis,” added Jason Campagna, M.D., Ph.D., Chief Medical Officer of Q32 Bio. “Auto-reactive T cells that have escaped immune regulation have a central role in autoimmune skin diseases, including AD, and ADX-914 has the potential to attenuate this pathology and help restore immune homeostasis by targeting both the IL-7 and TSLP signaling pathways.”

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