Asher Bio Presents New Preclinical Data at SITC 2022 Further Supporting Advancement of AB248 and AB821 as Highly Differentiated Cis-targeted Cancer Immunotherapies

— AB248 demonstrates non-clinical activity and safety profile suggesting its potential as a best-in-class IL-2 —

— AB821 shows differentiated anti-tumor activity and enhanced bioavailability over wild type IL-21 —

— On track to initiate Phase 1 trial of AB248 in 4Q 2022; Plan to file investigational new drug (IND) application for AB821 in 2H 2023 —

Excerpt from the Press Release:

SOUTH SAN FRANCISCO, Calif.–(BUSINESS WIRE)–Asher Biotherapeutics, Inc. (Asher Bio), a biotechnology company focused on developing therapies to precisely engage specific immune cells to fight cancer, chronic viral infection, and autoimmune disease, today announced new preclinical data for AB248, its CD8-targeted interleukin-2 (IL-2) immunotherapy, and for AB821, its CD8-targeted interleukin-21 (IL-21) immunotherapy. The data will be presented at the Society for Immunotherapy in Cancer (SITC) 37th Annual Meeting, being held in Boston, Massachusetts, on November 8-12, 2022.

We are very pleased to share new data for both AB248 and AB821 at SITC, showcasing the power of our platform to efficiently generate product candidates that demonstrate highly selective T cell engagement, as well as differentiated pharmacodynamics, anti-tumor activity and tolerability across a range of in vitro and in vivo models,” said Ivana Djuretic, Ph.D., Chief Scientific Officer and Co-Founder of Asher Bio. “These data provide further validation that our cis-targeting approach enables us to activate only the desired immune cell type, potentially overcoming the pleiotropic effects that limited the clinical potential of previous immunotherapies. We look forward to advancing both programs as we aim to deliver on the promise of IL-2 and IL-21 as high-value targets to improve the care and treatment of people living with cancer.”

New Preclinical Data for AB248, Asher Bio’s CD8-Targeted IL-2

In a poster presentation entitled, “CD8+ T cell selectivity of AB248 is essential for optimal anti-tumor activity and safety in nonclinical models,” lead author Kelly Moynihan, Ph.D., Senior Director and Project Team Leader at Asher Bio, described new preclinical data further differentiating AB248 from “not-α” IL-2 therapies and elucidating the mechanisms by which AB248 achieves enhanced anti-tumor activity and greater tolerability. T

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