Kira Pharmaceuticals Presents Complete Data from Phase 1 SYNERGY-1 Trial of KP104 at American Society for Nephrology Kidney Week 2022

Biomarker data demonstrates proof-of-concept for KP104’s dual-targeting mechanism via dose-dependent inhibition of alternative and terminal pathways and supports intravenous and subcutaneous administration of KP104 in phase 2 studies

Excerpt from the Press Release:

CAMBRIDGE, Mass., Nov. 3, 2022 /PRNewswire/ — Kira Pharmaceuticals, a global biotechnology company pioneering transformational complement therapies to treat immune-mediated diseases, today presented complete first-in-human data from its SYNERGY-1 trial of KP104 at the American Society of Nephrology (ASN) Kidney Week 2022 in Orlando, FL. KP104 is a first-in-class bifunctional biologic engineered to selectively target the alternative and terminal complement pathways.

“The data indicate that we can effectively regulate complement activity in healthy volunteers via simultaneous upstream and downstream inhibition at two key intervention points in the alternative and terminal pathways with our bifunctional asset KP104,” said Frederick Beddingfield, MD, PhD, CEO of Kira Pharmaceuticals. “Given the presence of complement in both healthy individuals and those living with chronic disease, we’re confident in the clinical translation of these results to patients and look forward to initiating Phase 2 evaluation of KP104 in a range of immunologic conditions with limited treatment options.”

Key biomarker data demonstrate dose-dependent inhibition by KP104 of the alternative pathway (AP) and terminal pathway (TP) of complement activation, as assessed by a C3b deposition assay and a free C5 assay, respectively. Biomarker assay also included a rabbit red blood cell (RBC) hemolysis assay which measures the combined inhibitory effect of KP104 on AP and TP.

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