Marengo Therapeutics Presents Preclinical Proof-of Concept Data for STAR0602, a First-in-class Selective T cell Activator, at the 34th EORTC-NCI-AACR Symposium 2022

• Compelling data with STAR0602 demonstrates potent, single agent anti-tumor activity in PD-1 refractory solid tumor models
• Distinct mechanism of action through expansion of a subset of Vβ T cells with a novel memory phenotype that promotes durable de novo antitumor immune responses
• STAR0602 slated to initiate Phase 1/2 clinical trial (START-001) in the fourth quarter of 2022

Excerpt from the Press Release:

CAMBRIDGE, Mass., Oct. 28, 2022 /PRNewswire/ — Marengo Therapeutics, Inc., a company pioneering novel therapeutics targeting the T cell receptor Vβ chain (TCR Vβ) to selectively activate the right T cell subsets to fight cancer, today presented the first preclinical proof-of-concept data on STAR0602, its novel TCR agonist antibody, during the 34^th EORTC-NCI-AACR Symposium on molecular targets and cancer therapeutics (ENA) in Barcelona, Spain. The data presented showed potent anti-tumor activity of STAR0602 in a range of solid tumor models, including those refractory to check point inhibitors like PD-1/PD-L1.

The plenary oral presentation was given by James Gulley, M.D., Ph.D., Co-Director of the Center of Immuno-Oncology (CIO), Deputy Director of the Center for Cancer Research (CCR) at the National Cancer Institute (NCI), and acting Clinical Director, NCI.

“STAR0602 offers an entirely new mechanism of selective T cell activation that increases both the quantity and quality of T cell responses to the tumor via a mechanism that is distinct to checkpoint inhibitors,” said Zhen Su, M.D., MBA, Chief Executive Officer of Marengo.

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