eClinical Technology and Industy News

Revelation Biosciences Inc. Announces Future Clinical Development Plans Based on Recent Biomarker Analysis and Significant Reduction in New Collagen Deposition (Fibrosis) in Preclinical Model

Excerpt from the Press Release:

SAN DIEGO, Calif.–(BUSINESS WIRE)–Revelation Biosciences Inc. (NASDAQ: REVB) (the “Company” or “Revelation”), a life sciences company that is focused on the development of immunologic based therapies for the prevention and treatment of disease, today announced that recently completed exploratory biomarker analysis has confirmed clinical development plans for REVTx-300 in the treatment of CKD and AKI. This new biomarker data is in addition to the previously-announced significant reduction in new collagen deposition (57%) observed in a preclinical fibrosis model and provides the potential for new intellectual property.

Reduction in new collagen deposition (fibrosis) helps maintain kidney function. Fibrosis or scarring, results in loss of normal kidney function. Loss of normal kidney function causes the build-up of toxic materials which leads to further deleterious health effects, propagation of chronic disease, and ultimately, death.

During the first half of 2023 Revelation plans to initiate a Phase 1a clinical study comprising 5 cohorts of single ascending doses and a 6th cohort of multiple doses of REVTx-300 to investigate safety and drug activity. Revelation plans to initiate a Phase 1b clinical study in patients undergoing elective cardiac surgery in the second half of 2023.

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