Cerevel Therapeutics Announces Publication in The Lancet of Emraclidine Data from Phase 1b Clinical Trial in People Living with Schizophrenia
Emraclidine is being developed as a potential once-daily treatment for schizophrenia without the need for titration
Data show clinically meaningful and statistically significant improvement with emraclidine in PANSS total score at six weeks and was overall well-tolerated compared with placebo
Results demonstrate selective targeting of the M4 muscarinic receptor subtype as a potential novel treatment approach for schizophrenia
Comprehensive Phase 2 development program in schizophrenia currently underway
Excerpt from the Press Release:
CAMBRIDGE, Mass., Dec. 15, 2022 (GLOBE NEWSWIRE) — Cerevel Therapeutics (Nasdaq: CERE), a company dedicated to unraveling the mysteries of the brain to treat neuroscience diseases, announced today the publication of data from its Phase 1b clinical trial of emraclidine, a novel muscarinic M4 selective positive allosteric modulator, in adults living with schizophrenia in The Lancet.
In the Phase 1b trial, both treatment groups of emraclidine (assessing 30 mg once daily and 20 mg twice daily) demonstrated clinically meaningful and statistically significant improvements in assessments of symptom severity (Positive and Negative Syndrome Scale (PANSS) total score) and emraclidine was generally well-tolerated compared with placebo after six weeks of treatment.
“We believe the data from the Phase 1b trial published in The Lancet support the potential of emraclidine to be an important treatment option with a novel mechanism of action for people living with schizophrenia,” said John H. Krystal, M.D., Robert L. McNeil, Jr. Professor of Translational Research and Professor of Psychiatry, of Neuroscience, and Psychology, and chair of the Yale Department of Psychiatry at Yale School of Medicine. “Emraclidine demonstrated clinically meaningful and statistically significant antipsychotic effects with no meaningful differences in gastrointestinal adverse events, extrapyramidal symptoms or weight gain compared with placebo.”
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