Coagulant Therapeutics Presents Data on an Exosite-Specific Nanobody Library to Activated Protein C (APC) at the 2022 American Society of Hematology (ASH) Annual Meeting
Oral presentation describes a unique APC nanobody library and its potential as a source for novel treatments to diseases including trauma, hemophilia, ischemia and sepsis.
Excerpt from the Press Release:
SAN FRANCISCO, Dec. 11, 2022 /PRNewswire/ — Coagulant Therapeutics Corporation, a privately held company focused on the design, development and commercialization of therapeutics targeted to the coagulation cascade and its adjacencies, announced data from pre-clinical studies on a novel llama-derived antibody (nanobody) library directed to the APC exosite. An oral presentation titled “Selective Modulation of Activated Protein C Activities by an Exosite-Specific Nanobody Library” will be presented at the American Society of Hematology Annual Meeting in New Orleans, Louisiana, December 10-13, 2022.
“This nanobody library not only offers potential treatments for acute bleeding conditions, such as trauma and hemorrhagic stroke, it also provides the opportunity to identify possible treatments in indications beyond acute bleeding where APC plays an important role, such as hemophilia and sepsis ,” said Terry Hermiston, Ph.D., founder and CEO of Coagulant Therapeutics. Dr. Hermiston pointed out that the different mechanisms of action between the APC-targeting molecules and the companies lead molecule, CT-001, an engineered highly potent, fast clearing FVIIa molecule, suggest that these molecules may actually complement one another in the clinic. “We are excited to explore their potential as additive or synergistic agents in the treatment of acute bleeds.”
The data, presented by Derek Sim, Ph.D., Chief Scientific Officer for Coagulant Therapeutics, described novel llama-derived nanobodies to the exosite of Activated Protein C (APC) that affected anticoagulation, histone cleavage and receptor mediated cleavage activities of APC. The characterization resulted in 13 novel activity profiles that can be employed to regulate specific APC functions for therapeutic purposes.
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