Electra Therapeutics highlights ELA026 Phase 1b study in sHLH and presents preclinical data at ASH Annual Meeting
- Ongoing Phase 1b study progressing in US and EU for ELA026 in sHLH, a life-threatening inflammatory disease
- Preclinical data demonstrate ELA026 proof-of-mechanism of SIRP targeting and depletion of pathological immune cells that drive sHLH
- Company also presents results of sHLH natural history study
Excerpt from the Press Release:
SOUTH SAN FRANCISCO, Calif.–(BUSINESS WIRE)–Electra Therapeutics, Inc., a clinical stage biotechnology company developing novel antibody therapies that target signal regulatory proteins (SIRP), today announced presentations and clinical progress for ELA026, the company’s first-in-class antibody in development for the treatment of secondary hemophagocytic lymphohistiocytosis (sHLH), a life-threatening inflammatory disease. Three poster presentations supporting the company’s clinical development of ELA026 in sHLH are highlighted at the 64th American Society of Hematology (ASH) Annual Meeting being held in New Orleans from December 10-13, 2022.
Electra also announced today that a Phase 1b global study of ELA026 in sHLH patients has been initiated and is ongoing (ClinicalTrials.gov identifier: NCT05416307). The Phase 1b study is highlighted as a clinical trial in progress poster at ASH, titled “A Phase 1b study of ELA026 in patients with secondary hemophagocytic lymphohistiocytosis.” The Phase 1b study is an open-label, single-arm, multicenter study which will evaluate the safety and efficacy of ELA026, assess biomarkers and identify a dose for Phase 2/3 testing.
“We are excited to advance ELA026 in the clinic as a novel approach targeting SIRP to address the aberrant myeloid and T cell activity that drives the sHLH disease process,” said Gary Patou, MD, Chief Medical Officer of Electra. “We have created a robust design for this Phase 1b study with the aim of progressing rapidly toward a Phase 2/3 study so we can accelerate ELA026 as a potential treatment option for sHLH patients in need.”
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