New Crown Bioscience Publication Details Application of In Vitro 3D Organoids with Matched PDX for Clinically Relevant Oncology Drug Development
Excerpt from the Press Release:
SAN DIEGO–(BUSINESS WIRE)–Crown Bioscience, a JSR Life Sciences company and Contract Research Organization (CRO), has announced the publication of its review paper entitled: Translational and Clinical Relevance of PDX-Derived Organoid Models in Oncology Drug Discovery and Development.
The paper is the first comprehensive review of tumor organoids derived from Patient Derived Xenograft (PDX) models across multiple cancer types. Developed from adult stem cells residing in the tumor, the paper describes the establishment of living biobanks of organoids readily available for drug discovery and development research. The paper was spearheaded by two senior scientists at Crown Bioscience, Dr Rajendra Kumari, Executive Director, Integrated Solutions and Dr Xiaoxi Xu, Senior Director, Molecular and Cellular Biology, and details how disruptive organoid technology was deployed to create matched 3D in vitro and in vivo patient-relevant systems.
Crown Bioscience’s paper highlights the robustness and reproducibility of 3D in vitro organoid technology as well as the genetic and phenotypic stability compared to the original tumor material. PDX collections from different cancer types now have 3D in vitro matched models that can be scaled up for higher throughput screens and used repeatedly for multiple studies or applications.
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