Partner Therapeutics Announces Publication of a Retrospective Cohort Review of 15 LEUKINE® Treated Patients with Pediatric Malignancies and Invasive Fungal Disease Refractory to Antifungal Therapy

Excerpt from the Press Release:

LEXINGTON, Mass., Dec. 15, 2022 /PRNewswire/ — Partner Therapeutics, Inc. (PTx) announced publication of a single institution retrospective cohort review of 15 patients with pediatric malignancies and invasive fungal diseases that were refractory to antifungal therapy and treated adjunctively with Leukine (sargramostim; yeast-derived, glycosylated recombinant human granulocyte-macrophage colony-stimulating factor [rhu GM-CSF]).¹ Additionally, the publication included a systematic review of 50 published reports of rhu GM-CSF use for invasive fungal disease. Open Forum Infectious Diseases published the manuscript entitled “Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (rhu GM-CSF) as Adjuvant Therapy for Invasive Fungal Diseases.” Leukine is not approved to treat invasive fungal disease.

The authors conclude: “Sargramostim may be a potential adjunctive immunomodulator for selected patients with hematological malignancies and refractory [invasive fungal diseases] IFDs.” The overall response rate for sargramostim use in the retrospective cohort was 92%. 80% of patients were refractory to antifungal therapy prior to sargramostim use. The infections were caused by Candida spp., Trichosporon sp., and molds (Aspergillus spp., Scedosporium sp), as well as the mucormycosis-causing pathogens Rhizopus sp., Lichtheimia sp.

Endogenous GM-CSF functions as a hematopoietic growth factor while also regulating the broader immune system via activation of macrophages, monocytes, and neutrophils.²

Click the button below to read the entire Press Release:

Continue Reading The Press Release