Allogene Therapeutics Publishes Preclinical Data in Clinical Cancer Research Supporting DLL3 as a Potential AlloCAR T™ Target for Small Cell Lung Cancer
Preclinical Efficacy and Safety Results Indicate AlloCAR T™ Development Candidate Controls Tumor Growth without Off-Tumor/Normal Tissue Toxicity
Excerpt from the Press Release:
SOUTH SAN FRANCISCO, Calif., Jan. 25, 2023 (GLOBE NEWSWIRE) — Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T™) products for cancer, today announced the publication of a preclinical study demonstrating delta-like ligand 3 (DLL3) is a promising tumor target for AlloCAR T™ in small cell lung cancer (SCLC). The findings were published in Clinical Cancer Research, a journal of the American Association for Cancer Research (AACR).
SCLC is an aggressive disease with limited treatment options. Approximately 30,000 patients in the United States are affected each year with this disease which has a 5-year overall survival rate of approximately 7%.1 DLL3, with high expression on tumors and limited expression in normal tissue, is a promising target for SCLC and potentially other solid tumors.
“As a leader in allogeneic CAR T research and development, we are committed to exploring the potential of this therapeutic modality across a broad range of indications, including in solid tumors where there is significant need,” said Barbra Sasu, Ph.D., Chief Scientific Officer at Allogene.
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