Alterity Therapeutics Launches ATH434 Phase 2 Clinical Trial in Italy for the Treatment of Individuals with Multiple System Atrophy

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Excerpt from the Press Release:

MELBOURNE, Australia AND SAN FRANCISCO, Jan. 25, 2023 (GLOBE NEWSWIRE) — Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) (“Alterity” or “the Company”), a biotechnology company dedicated to developing disease modifying treatments for neurodegenerative diseases, today announced the Company’s Phase 2 clinical trial of ATH434 for the treatment of patients with Multiple System Atrophy (MSA) is now open for enrollment in Italy.

“Expanding our presence in another major European country is important as we continue to broaden access to our ATH434 Phase 2 clinical trial to individuals living with MSA,” said David Stamler, M.D., Chief Executive Officer, Alterity. “Current therapies for MSA only treat the symptoms of the disease whereas ATH434 is a potential disease modifying therapy designed to address the underlying pathology of MSA. Our trial sites in Europe, Asia-Pacific, and the U.S. are now actively recruiting participants with early-stage MSA as we continue our commitment to bring a much-needed treatment to individuals living with this devastating condition.”

The Phase 2 clinical trial is a randomized, double-blind, placebo-controlled investigation of ATH434 in patients with early-stage MSA. The study will evaluate the effect of ATH434 treatment on neuroimaging and protein biomarkers to demonstrate target engagement and clinical endpoints to demonstrate efficacy, in addition to assessments of safety and pharmacokinetics.

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