KalVista Pharmaceuticals Announces Publication of Sebetralstat Phase 2 Data in The Lancet
Excerpt from the Press Release:
CAMBRIDGE, Mass. & SALISBURY, England–(BUSINESS WIRE)–KalVista Pharmaceuticals, Inc. (NASDAQ: KALV), a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of oral, small molecule protease inhibitors today announced that results from the phase 2 trial evaluating the efficacy and safety of oral sebetralstat for the on-demand treatment of hereditary angioedema (HAE) attacks has been published in the international weekly medical journal, The Lancet.
The phase 2 study was a two-part, randomized, double-blind, placebo-controlled clinical trial. The trial included a total of 68 patients with HAE and showed that oral sebetralstat was well tolerated and led to rapid suppression of plasma kallikrein activity, resulting in significantly increased time to use of conventional treatment, reduced attack severity, and faster time to symptom relief and resolution compared to placebo.
“All currently available on-demand treatments in HAE require injections and are associated with substantial treatment burden and delays due to the time required for medication preparation and administration, and associated pain and discomfort,” said Dr. Emel Aygören-Pürsün, Head of the HAE Center at the University Hospital Frankfurt, co-lead author of the manuscript, and Principal Investigator for the phase 2 clinical trial.
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