eFFECTOR Therapeutics Reports Positive Data Updates from Phase 2 Expansion Cohorts Evaluating Zotatifin in Patients with ER+ Metastatic Breast Cancer at the ASCO 2023 Annual Meeting

• Partial responses observed in 5 of 19 (26%) evaluable patients treated with zotatifin 0.07 mg/kg combined with fulvestrant and abemaciclib (ZFA triplet) in heavily pretreated population
• Partial response observed in 1 of 3 (33%) patients treated with zotatifin 0.1 mg/kg combined with fulvestrant (ZF doublet)
• Both combinations were generally well tolerated with large majority of adverse events Grade 1 or 2
• Company will host a virtual investor call on June 4, 2023, to discuss the data and clinical progress

Excerpt from the Press Release:

eFFECTOR Therapeutics, Inc. (NASDAQ: EFTR), a leader in the development of selective translation regulator inhibitors (“STRIs”) for the treatment of cancer, today announced positive interim data updates from a Phase 2 expansion cohort evaluating zotatifin combined with fulvestrant and abemaciclib (ZFA triplet) in patients with ER+ metastatic breast cancer (mBC). These data, as well as initial data from further dose escalation, will be presented as a poster at the American Society of Clinical Oncology (ASCO) Annual Meeting, taking place June 2-6 in Chicago, IL by Ezra Rosen, M.D. from Memorial Sloan Kettering Cancer Center (MSK). The Company will host a virtual investor call on Sunday, June 4, 2023, at 6:30 PM CT / 7:30 PM ET to discuss the data and clinical progress. Sarat Chandarlapaty, M.D., Ph.D. of MSK will join the call to discuss the unmet medical need and current treatment landscape for patients with ER+ mBC.

“The activity observed with the ZFA triplet, with partial responses seen in 26% of patients, is substantially higher than we would expect for treating such heavily pretreated patients with just fulvestrant and abemaciclib,” said Steve Worland, Ph.D., president and chief executive officer of eFFECTOR. “We believe this activity level reflects in part zotatifin’s mechanism of down-regulating cyclins D and E, and the synergy this provides with CDK4/6 inhibition. The partial response observed at a higher dose of zotatifin in combination with only fulvestrant is encouraging and we look forward to reporting data from the completed dose escalation in the second half of 2023.”

“I am excited about the early efficacy and safety results of the novel therapeutic candidate zotatifin and look forward to continuing its development in patients with advanced ER+ breast cancer who are currently medically underserved,” added Doug Warner, M.D., chief medical officer of eFFECTOR.

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