Cantabio Pharmaceuticals Receives Additional Grant from The Michael J. Fox Foundation for Testing Its Novel Redox DJ-1 Protein-based ELISA Platform for the Diagnosis of Parkinson’s Disease
Grant enables the application of Cantabio’s Redox DJ-1 ELISA platform for the quantification of specific oxidized states of DJ-1 in Parkinson’s disease patients’ bio-samples, such as iPSC-derived dopaminergic neurons, post-mortem brain tissue and plasma, for the development of a new biomarker potentially for early diagnosis of and tracking the progression of Parkinson’s disease
Excerpt from the Press Release:
SAN MATEO, CA / ACCESSWIRE / August 17, 2023 / Cantabio Pharmaceuticals, Inc. (“Cantabio” or the “Company”), a preclinical stage pharmaceutical company developing disease modifying therapeutics for Alzheimer’s disease (AD), Parkinson’s disease (PD) and other aging related diseases, today announced that The Michael J. Fox Foundation for Parkinson’s Research (MJFF) has awarded the Company a major grant entitled “Quantification of Cys106 of DJ-1 in Distinct Redox States in Parkinson’s Patients’ iPSC-derived Dopaminergic Neurons, Postmortem Brain Tissue and Plasma as a Potential Biomarker of Parkinson’s Disease”. This grant funds the Company’s on-going DJ-1 focused biomarker research program aiming on diagnosing early on-set and tracking the progression of PD.
Currently no available validated tests exist for quantifying clinical biomarkers of PD. Thus, this is an area of critical unmet need both for the early diagnosis and progression of the disease. Moreover, such tests are crucial for the development of disease modifying therapeutics and the early treatment of the disease. Therefore, it represents a large commercial market for an approved solution.
The funded project targets DJ-1, a protein genetically linked to early-onset of familial PD, which acts as a vital defensive protein, protecting cells from damage caused by biochemical stress such as oxidative and glyoxal stress and protein aggregation.
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