Astria Therapeutics Announces Publication of STAR-0215 Preclinical Data in the Journal of Pharmacology and Experimental Therapeutics

Excerpt from the Press Release:

BOSTON–(BUSINESS WIRE)–Astria Therapeutics, Inc. (NASDAQ:ATXS), a biopharmaceutical company developing STAR-0215 for the treatment of hereditary angioedema (HAE) and focused on life-changing therapies for rare and niche allergic and immunological diseases, today announced that preclinical data supporting STAR-0215’s profile as a potential long-acting therapy for hereditary angioedema (HAE) dosed once every three or six months has been published in the Journal of Pharmacology and Experimental Therapeutics.

“We were very pleased by our publication in the Journal of Pharmacology and Experimental Therapeutics, further validating the exciting science behind STAR-0215,” said Jill C. Milne, Ph.D., Chief Executive Officer at Astria Therapeutics. “These results demonstrate that STAR-0215 is a potential best-in-class plasma kallikrein inhibitor as it shows high potency in vitro and in vivo and long half-life, suggesting potential for sustained, durable HAE attack suppression with subcutaneous administration.”

Overview of STAR-0215 Preclinical Results:

• STAR-0215’s YTE modification in the Fc domain enhances FcRn receptor binding, resulting in a ~3-fold prolonged half-life in cynomolgus monkeys compared to antibodies without this modification.
• STAR-0215 has a >1000-fold lower affinity for prekallikrein and no measurable inhibitory activity against other serine proteases, demonstrating potent and specific binding for STAR-0215 for human plasma kallikrein.

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